Treating bladder cancer
Treatment for bladder cancer
Planning your treatment
The treatment for bladder cancer depends on the type of cancer and the stage and grade. In most hospitals, a team of specialists will meet to discuss and agree on the plan of treatment they feel is best for your situation. This multidisciplinary team (MDT) will normally include:
Other staff will also be available to help you if necessary, such as:
Your doctors will discuss with you what the best treatment is for your particular situation. If you have any questions about your treatment, don't be afraid to ask your doctor or the nurse looking after you. It often helps to make a list of the questions you want to ask and to take a close friend or relative with you to help you remember what is discussed.
If two treatments are equally effective for your type and stage of cancer, your doctors may offer you a choice of treatments. Sometimes people find it very hard to make a decision. If you are asked to make a choice, make sure that you have enough information about the different treatment options, what is involved and the side effects you might have, so that you can decide what is the right treatment for you.
Before you have any treatment, your doctor will explain the aims of the treatment to you. They will usually ask you to sign a form saying that you give your permission (consent) for the hospital staff to give you the treatment. No medical treatment can be given without your consent, and before you are asked to sign the form you should have been given full information about:
If you do not understand what you have been told, let the staff know straight away so that they can explain again. Some cancer treatments are complex, so it is not unusual for people to need repeated explanations.
It's often a good idea to have a friend or relative with you when the treatment is explained, to help you remember the discussion more fully. You may also find it useful to write down a list of questions before you go to your appointment.
Patients often feel that the hospital staff are too busy to answer their questions, but it is important for you to be aware of how the treatment is likely to affect you. The staff should be willing to make time for you to ask questions.
You can always ask for more time to decide about the treatment if you feel that you can't make a decision when it is first explained to you.
You are also free to choose not to have the treatment. The staff can explain what may happen if you do not have it. It is essential to tell a doctor, or the nurse in charge, so that they can record your decision in your medical notes. You do not have to give a reason for not wanting to have treatment. However, it can be helpful to let the staff know your concerns so that they can give you the best advice.
Usually a number of cancer specialists work together as a team and they use national treatment guidelines to decide on the most suitable treatment for a patient. Even so, you may want to have another medical opinion. Either your
specialist or GP will be willing to refer you to another specialist for a second opinion, if you feel it will be helpful. Getting a second opinion may cause a delay to the start of your treatment, so you and your doctor need to be confident that it will give you useful information.
If you do go for a second opinion, it may be a good idea to take a friend or relative with you, and to have a list of questions ready so that you can make sure your concerns are covered during the discussion.
Treatment for carcinoma in situ
Carcinoma in situ, or CIS, is a very early bladder cancer. As it can be quickly growing, the treatment may be more intensive than for other types of early bladder cancer. The usual treatment is removal of the area of CIS by surgery. The surgery is followed by treatment of the inside of the bladder (intravesical therapy) with either chemotherapy or BCG. This can get rid of the CIS in up to 60% (6 in 10) of people.
If the CIS does not go away completely or comes back after treatment, further treatment with surgery, chemotherapy or BCG will be needed. Your doctor can talk to you about the most appropriate treatment in your situation.
Treatment for early bladder cancer
Early (superficial) bladder cancers are usually small growths (papillary cancers) and there may be more than one. The cancer or cancers can be usually removed surgically, using a cystoscope (see diagnosis).
Surgery is the main treatment for early bladder cancer. It may be the only treatment that is needed or it may be combined with drug treatment given into the bladder.
Before surgery you will have a blood test to check your general health. You will also have a chance to discuss the surgery with a specialist nurse or a doctor. You'll have a medical examination to make sure that you are fit enough to have an anaesthetic.
You will be admitted to the surgical ward on the day of surgery, or the day before. The anaesthetist will talk to you about your operation and ask you to sign a consent form. A research nurse may ask you for permission for blood samples and some of the tissue taken at the time of surgery to be kept and used for research. If you agree to this, you will be asked to sign a second consent form.
You will be given a general anaesthetic and a cystoscope will be inserted into the bladder. The tumour is cut out or burnt off (cauterised), using a mild electrical current. This procedure is known as a transurethral resection of a bladder tumour.
Transurethral means through the fine tube (urethra) which is connected to the bladder (see diagram of the bladder). The whole procedure is done in this way and several tumours can be treated at the same time, if necessary. You won't be left with any scar because there's no wound.
The operation usually takes from 20 minutes to an hour. You may be given chemotherapy into your bladder immediately after surgery.
After the operation
When you go back to the ward you will have a thin, flexible tube (a catheter) in your bladder, which drains your urine into a bag. It may make you feel as though you want to pass urine. Your urine will be bloodstained at first. Large bags of fluid may also be used to flush out the bladder continuously. This is to make sure that clots of blood do not form and block the urethra.
Once you are drinking normally and your urine looks clear, the catheter will be taken out. This is not painful but may feel a little uncomfortable. Once your catheter has been removed and your urine is no longer bloodstained, you will be allowed to go home. This is usually about 2-3 days after the operation.
Possible risks of surgery
Removing early bladder cancers is a safe procedure. However, it can have some risks. These are outlined below.
Urine infection Between 5-10 out of every 100 patients (5-10%) may get a urine infection. This may be while they are still in hospital or after they go home. Signs of an infection include: feeling cold, shivery, hot or sweaty; feeling generally ill; or your urine becoming smelly or cloudy. If you think you may have an infection, you can take a urine sample to your doctor for testing.
Bleeding for more than a few days occurs in up to 5 out of 100 patients (5%) and a blood transfusion may be needed. If the bleeding does not stop on its own, another operation to stop the bleeding may need to be done under anaesthetic.
You may find that you have some further bleeding about 10-14 days after the operation to remove your cancer. This usually stops on its own after a couple of days. If the bleeding lasts for longer than this, or if you can see clots of blood, get in touch with your doctor.
Damage to the bladder There is a very small risk of a hole (perforation) being made in the bladder during surgery. If this happens it can usually be managed by having a catheter in the bladder (for about a week to 10 days) to drain the urine and allow the hole to heal.
If the hole does not heal in that time, you may need to have an operation to seal it. This involves making a cut in the abdomen. Your doctor or nurse will explain this procedure if it is needed.
After your operation your doctors will know more about the stage of your cancer. This information along with the grade of your cancer helps them decide on the most appropriate treatment for you.
You may be advised to have further treatment with chemotherapy or BCG to reduce the chances of the cancer coming back (recurring) or growing into the muscle (becoming invasive).
Chemotherapy into the bladder (intravesical chemotherapy)
After your surgery you may be given chemotherapy directly into your bladder to reduce the risk of your cancer coming back in the bladder. When chemotherapy is given directly into your bladder it is described as intravesical.
Chemotherapy works by destroying cancer cells. When it's given into the bladder the drug comes into direct contact with any cancer cells in the lining of the bladder. Because it's given into the bladder and not through a vein (into the bloodstream) you won't get side effects like feeling sick or hair loss, which people usually associate with chemotherapy. Hardly any of the drug is absorbed into the bloodstream which means that it doesn't affect the rest of the body.
When it's used
Most people with early bladder cancer will have a one-off treatment of chemotherapy into the bladder. This is usually given a few hours after your operation to remove the bladder cancer. Some people only have one treatment while others go on to have a course of treatment. People with low grade early bladder cancer won't usually need any further treatment. If you have a moderate risk of your cancer coming back in the bladder you will usually have a course of chemotherapy into the bladder. This can include people who have:
Treatment is usually given once a week for about six weeks.
How it's given
If you're having chemotherapy into your bladder after surgery you'll already be in hospital and will have a catheter (small tube into your bladder) in place. The treatment is usually given a few hours after the surgery. It may be delayed until the following day if you have a lot of blood in your urine.
After this, if you are having more chemotherapy, it will be given to you in the hospital outpatient department. You can go home as soon as it's finished. It might be a good idea to ask someone to collect you, particularly the first time.
You're usually asked to limit the amount you drink before your treatment. If you drink too much before treatment your bladder may feel uncomfortably full. Drinking less also helps to increase the concentration of the chemotherapy drug in your bladder. If you normally take water tablets (diuretics) take them later in the day after your treatment. Let your doctor know about any other medicines you are taking. You won't be given chemotherapy if you are unwell or have an infection in your urine. Your nurse or doctor will give you more advice about preparing for your treatment.
You'll have a fine tube (catheter) put into your bladder. Your doctor or nurse will then put the chemotherapy drug (a liquid) directly into your bladder through the catheter. The drugs that are most commonly used are mitomycin-C and epirubicin. The catheter is then usually removed.
Usually you'll be asked to try not to pass urine for at least an hour after the drug has been put into your bladder. This can be difficult but it's to give the treatment time to work. Sometimes the catheter is left in and clamped to keep the chemotherapy in your bladder until your treatment is over. You can walk around during this time. When the treatment is finished you can go to the toilet or, if you have a catheter, the chemotherapy drug will be drained into a urine bag before the catheter is removed.
After treatment there are some precautions you'll need to take to protect yourself and others from coming into contact with the chemotherapy drug. To avoid splashing urine on the toilet seat it might be easier for men to pass urine sitting down.
You'll be asked to wash the skin in your genital area carefully with soap and water after you pass urine. This is to make sure any of the chemotherapy drug that may have splashed onto your skin is then wiped off. It's also important to wash your hands afterwards. Your nurse or doctor will give you more advice about this.
The following side effects are due to inflammation of the bladder lining (cystitis):
These side effects should settle down within a day or two. Drinking lots of fluids will help ease the irritation. You might find it helpful to take mild painkillers. Occasionally some people get a red skin rash on their hands and feet. Let your nurse or doctor know if this happens.
If your side effects don't improve or you have a raised temperature and your urine is smelly (possible signs of a urine infection) get in touch with your doctor straightaway.
It isn't advisable to become pregnant or father a child while having chemotherapy drugs to treat bladder cancer, as they may harm the developing foetus. It is important to use effective contraception during your treatment. You can discuss this with your doctor or specialist nurse.
Men should use a condom during sex for the first 48 hours after chemotherapy. If you are a woman having the treatment your partner should use a condom. Using a condom will protect your partner from any of the drug that may be present in semen or vaginal fluid.
BCG into the bladder (intravesical treatment)
BCG is a vaccine which is used to prevent tuberculosis (TB). But it's also a helpful treatment for some early bladder cancers. When BCG goes directly into the bladder the treatment is described as intravesical. BCG is a type of immunotherapy. Immunotherapy stimulates the body's immune system to destroy cancer cells. Doctors aren't sure
exactly how BCG works. It seems that the vaccine makes the bladder react in a way that triggers the body's immune system to get rid of cancer cells in the bladder.
When BCG is used
BCG is usually given to people with early bladder cancer who have a high risk of the cancer coming back and of growing into the muscle (invasive). This can include people who have:
BCG stops the cancer from coming back in the bladder and also reduces the chances of it spreading into the muscle (becoming invasive).Your specialist will explain why BCG is the most appropriate treatment for you.
You will usually have your treatment once a week for six weeks. If your BCG treatment is working well for you it can be given every six months, once a week for three weeks (called maintenance therapy).
Maintenance therapy can continue for up to three years. Your specialist will talk to you about how long your treatment will go on for.
How it's given
BCG treatment is given to you in the hospital outpatient department. It takes up to three hours and you can usually go home as soon as it's finished. It might be a good idea to ask someone to collect you, particularly the first time.
Unlike chemotherapy into the bladder, BCG treatment is never given immediately after surgery to remove bladder tumours. There needs to be a delay usually of at least two weeks after surgery, before you can have it. You won't be given treatment with BCG if you are unwell or have an infection in your urine.
You're usually asked to limit the amount you drink before your treatment. This will help to increase the concentration of BCG in your bladder. Drinking too much before your treatment may make your bladder feel uncomfortably full. If you normally take water tablets (diuretics) take them later in the day after your treatment. Your nurse or doctor will give you more advice about preparing for your treatment.
You'll have a fine tube (catheter) put into your bladder. Your doctor or nurse will then put the vaccine (a liquid) directly into your bladder through the catheter. You will need to try not to pass urine for two hours afterwards. This can be difficult but it's to give the treatment time to work. Sometimes the catheter is left in and clamped to keep the BCG in your bladder for the next two hours. You can walk around during this time. When the treatment is over you can go to the toilet (if you don't have a catheter). If you have a catheter the BCG will be drained into a urine bag before the catheter is removed.
After your treatment there are some precautions you'll need to take. This is because BCG is a live vaccine and other people shouldn't be exposed to it.
For the next six hours, you'll need to avoid your urine splashing on the toilet seat and getting any urine on your hands. It might be easier for men to sit down when they're using an ordinary toilet although using a stand up urinal should be alright. The main thing is to avoid splashing urine and spreading the vaccine. You will also be asked to put undiluted bleach into the toilet bowl to destroy any live vaccine and leave it for 15 minutes until you flush. Your nurse or doctor will give you more advice about this.
Because BCG goes directly into the bladder most of the side effects are linked with the bladder. They usually go away within one to two days after your treatment. The most common ones are:
These side effects should settle down within a day or two. If they don't get better contact your doctor. Drinking lots of fluids can help flush the drug out of your bladder and reduce some of these effects. Taking simple painkillers can also help.
Rare side effects can include a continuing high temperature (fever), pain in your joints and a cough. If you have any of these symptoms, or if you feel generally unwell, contact your doctor immediately. These symptoms could be a sign of a more serious infection (due to BCG) that needs to be treated immediately. If this happens you'll be treated with the same drugs (antibiotics) that are used to treat TB.
Men should use a condom during sex for the first 48 hours after their treatment. If you are a woman who has had BCG treatment then your partner should use a condom. Using a condom will protect your partner from any vaccine present in your semen or vaginal fluid.
We don't know how BCG may affect a developing foetus so it's not advisable to become pregnant or father a child while having it. It is important to use effective contraception during your treatment and for six weeks afterwards. You can discuss this with your doctor or specialist nurse.
Treatment for invasive bladder cancer
Surgery or radiotherapy
Surgery or radiotherapy are the main treatments for invasive bladder cancer.
Surgery usually involves removing the bladder so you will pass urine differently from before.
Radiotherapy uses high-energy rays to destroy the cancer cells. It means that you will still have your bladder. Radiotherapy causes side effects and for some people the side effects may be long-term. If the cancer comes back after radiotherapy you may still need to have your bladder removed.
Your specialist may advise you which treatment is more suitable for you. For example, if you have a medical condition which makes the risks of surgery greater, then radiotherapy may be advised. If you have a larger tumour then surgery may sometimes be recommended.
Some people are offered a choice of having either surgery or radiotherapy. In some situations each treatment has the same chance of curing the cancer but also has its own benefits and disadvantages. Your specialist will talk this over with you so that you have enough information to decide which treatment is right for you.
Chemotherapy You may also be given chemotherapy (anti-cancer drugs) into a vein to shrink the tumour before your surgery or radiotherapy. This is called neo-adjuvant chemotherapy. It's given to reduce the risk of your cancer coming back later on.
Some people are given chemotherapy at the same time as radiotherapy (chemoradiation). This is to make the radiotherapy more effective.
Chemotherapy is also sometimes given after surgery to try and reduce the risk of the cancer coming back. This is called adjuvant chemotherapy. It's usually given as part of a clinical trial because it's not yet clear how helpful it is.
Benefits and disadvantages of treatments
The benefits of treatment will vary depending on each person's individual situation. In people with invasive bladder cancer, treatment is usually done with the aim of curing the cancer or controlling it for a long time.
Surgery (total cystectomy)
Surgery for invasive bladder cancer
The most common surgery is an operation to remove your bladder (radical cystectomy). You may be given chemotherapy to shrink the cancer before your surgery.
Cystectomy can be carried out in people with invasive or locally advanced bladder cancer (see staging). Some people whose bladder cancer has come back after being treated with radiotherapy may be able to have a cystectomy (known as salvage cystectomy).
Cystectomy is also sometimes done in people with early (superficial) bladder cancer that keeps coming back after treatment.
Your doctor will explain which is the most appropriate type of operation for you.
Occasionally an operation to remove part of the bladder (partial cystectomy) is done. After this operation people are able to pass urine as usual. However, as the bladder is smaller and holds less urine, they need to pass urine more often.
In this operation the whole bladder is removed. In men, the prostate gland, part of the urethra, and the lymph nodes close to the bladder are also taken away.
In women, the bladder, womb, cervix, nearby lymph nodes and part of the urethra are removed.
Men usually become impotent (unable to get or maintain an erection) and women may find that sensations during sexual intercourse are different from before the operation. The effects of surgery on your sex life are explained in more detail later on in this booklet.
After your bladder has been removed the urine made by your kidneys will need to be collected and stored differently from before. Your surgeon will make a new storage place for urine or sometimes make a new bladder. This is done at the same time as your cystectomy. There are several different operations which you may have: urostomy, bladder reconstruction, continent urinary diversion or uro-rectal conduit.
Your surgeon will explain which type of operation is most suitable for you and give you more information about what is involved. These operations are only carried out by specialist surgeons.
A urostomy (or ileal conduit) is the most common operation and it means your urine will be collected in a bag. During the operation the surgeon removes a section of your small bowel and joins the two ureters to one end of it. They bring the other open end of the bowel out through the skin of your abdomen.
The ureters carry urine from your kidneys to the piece of bowel. The piece of small bowel (ileum) acts as a channel (conduit) to take the urine to the surface of the abdomen. This is why this operation is sometimes called an ileal conduit. The small hole on the surface of the abdomen, through which the urine now passes out of the body, is called a stoma.
A flat, watertight bag is placed over the stoma to collect your urine. It's kept in place with a special type of adhesive. The bag will fill with urine and you'll need to empty it regularly. Your specialist stoma nurse will show you how to take care of it.
See further information on living with a urostomy.
Continent urinary diversion
This operation means you don't need to have a bag to collect your urine. A piece of your bowel is used to make a pouch to store your urine inside your abdomen. The ureters are attached to the piece of bowel and carry urine from your kidneys to be stored in the new pouch. The end of the piece of bowel is brought out onto the surface of the abdomen to make a stoma.
A small plastic tube (catheter) can be passed through the stoma into the pouch about 4 or 5 times a day to drain the urine. This is called self-catheterisation. Although you may feel worried about doing this at first, most people find they are good at managing self-catheterisation and at caring for their stoma. Your specialist stoma nurse will show you how to do this.
Sometimes your bladder can be replaced by using a piece of the small or large bowel to make a new bladder. This operation is known as bladder reconstruction (neobladder) and it can be done in different ways.
Bladder reconstruction is not suitable for everyone. For example, it's only done if there is no spread of the cancer to the urethra (the tube though which urine is passed). Your doctor will explain if this type of operation is appropriate for you.
Usually your doctor will remove a piece of your bowel, make it into a balloon-shaped sac and stitch it to the top of your urethra. The ureters are stitched into this new bladder so that urine drains directly into it from the kidneys.
The new bladder is emptied by flexing your abdominal muscles. You will need to remember to empty it, as you will have lost the nerves that tell you when your bladder is full. Sometimes this nerve loss can lead to incontinence (leaking of urine), especially when you are asleep. Twenty to thirty per cent of people (2 or 3 out of every 10 people) will have some incontinence.
Most people learn how to pass urine through the urethra. However, some people find it difficult and need to drain the urine regularly by passing a catheter (small plastic tube) into the urethra.
There's a small risk that the cancer could come back in the urethra, so you will have a test every year to check for this. The test is similar to having a cystoscopy.
It is sometimes possible to divert the urine into the rectum so that both urine and stools are passed through the back passage (rectum). If this is done the person does not need a urostomy bag, or to pass a catheter to drain the urine.
You may be nursed in the intensive care or high-dependency unit immediately after your operation. This is routine in many hospitals and does not mean your operation has gone badly or that there are complications.
The nurses will encourage you to start moving about as soon as possible after your operation. This is an essential part of your recovery, as it helps to prevent problems such as chest infections or blood clots. If you have to stay in bed the nurses will encourage you to do regular leg movements and deep breathing exercises. A nurse or a physiotherapist can help you to do the exercises.
Drips and drains
After the operation you may have some of the following in place for a short time:
After your operation you will need painkilling drugs for a few days. These may be given into a vein (intravenously), into the space around your spinal cord (epidural), into a muscle (intramuscularly) or as tablets.
To begin with you may be given intravenous painkilling drugs through a syringe connected to an electronic pump. The pump can be set to give you a continuous dose of painkiller. You may also have a hand control with a button you can press if you are in pain. This is called patient controlled analgesia (PCA). It's designed so that you can't overdose, so it's okay to press it whenever you are uncomfortable.
Some people are given painkilling drugs into the space around the spinal cord (epidural) to numb the nerves. The drugs are often given through a syringe and tubing attached to an electronic pump.
If you are in pain, let your nurses and doctors know as soon as possible. This will help them to give you the combination and dose of painkillers that is right for you.
How long you are in hospital for after your operation will depend on the type of operation you've had. It can range from 7 to 14 days. If you think that you might have problems when you go home - if you live alone or have flights of stairs to climb, for example - tell your nurse or social worker. They can arrange help for you before you leave hospital.
Your doctor will advise you about how soon you will be able to get back to doing normal things, like work, driving, shopping, gardening or playing sport. This will vary depending on the surgery you have had and on you as a person.
Before you leave hospital you will be given an outpatient appointment to attend. This will be a check-up for a few weeks after your surgery and is a good time to discuss any problems you may have after your operation.
Changes to your appearance
You may be worried about adapting to changes in how your body looks, and how you may feel about your body after any surgery. This is a normal reaction, as over the years we all develop an image in our minds about what our bodies look like. Although we may not be completely satisfied with that image, most people are used to the way they see themselves. It can be upsetting to have that image changed permanently by surgery (especially if you have a stoma).
You may also be concerned about the effect that the surgery will have on your relationships. You may be worried about rejection, continuing to have sex with your partner, or starting a new relationship. Many people find that they feel reassured once they're able to talk about their fears with their partner. Talking about your feelings can also help you to feel clearer about what worries you the most. It gives other people the chance to understand more about how you are feeling. You can also talk to your doctor or nurse about your concerns and support organisations can also give support.
Radiotherapy for invasive bladder cancer
Radiotherapy treats cancer by using high-energy rays, which destroy the cancer cells while doing as little harm as possible to normal cells
When it is given
Invasive bladder cancer
Radiotherapy for bladder cancer is often given instead of an operation to remove your bladder. However, if the cancer comes back later on you may still need to have your bladder removed. You will need to have cystoscopies (usually every three months or so) after your radiotherapy to check that the cancer has not come back.
You may have chemotherapy given before your radiotherapy treatment. Some people can have chemotherapy at the same time as their radiotherapy to help make radiotherapy more effective. This is called chemoradiation.
Advanced bladder cancer
If your cancer has spread outside the bladder to other parts of the body you may be given a short course of radiotherapy to the bladder. This can help to shrink the cancer and relieve symptoms that it may be causing. If your cancer has spread to the bones you may be given radiotherapy to help to relieve pain.
Our booklet on secondary bone cancer may be useful.
When you're having radiotherapy to relieve symptoms it's usually only given for a few minutes over one to three days. This means that you don't get many side effects or if you do they only last for a very short time. This type of radiotherapy is called palliative radiotherapy because it's given to ease (palliate) symptoms.
This treatment is normally given in the hospital radiotherapy department as a series of short daily sessions. The treatments are usually given from Monday to Friday, with a rest at the weekend. Each treatment takes 10-15 minutes. Your doctor will discuss the treatment and possible side effects with you.
A course of radiotherapy for bladder cancer may last 4-7 weeks. It's usually given to you as an outpatient. If you are having radiotherapy to relieve symptoms you will usually only need a few short sessions.
External radiotherapy does not make you radioactive and it is completely safe for you to be with other people, including children, throughout your treatment.
Radiotherapy has to be carefully planned to make sure that it is as effective as possible. This may take a few visits. On your first visit to the radiotherapy department, you will be asked to lie under a machine called a simulator, which takes x-rays of the area to be treated.
The treatment is planned by a cancer specialist (clinical oncologist). Marks are usually drawn on your skin to help the radiographer (who gives you your treatment) to position you accurately and to show where the rays will be directed. These marks must stay visible throughout your treatment, and permanent marks (tiny tattoos) may be used. These are tiny and will only be done with your permission. It may be a little uncomfortable.
At the beginning of each radiotherapy session, the radiographer will position you carefully on the couch, and make sure you are comfortable. During your treatment you will be left alone in the room but you will be able to talk to the radiographer who will be watching you from the next room. Radiotherapy is not painful but you do have to lie still for a few minutes while the treatment is being given.
After positioning you will be left alone for a few minutes while treatment is given, but you can still talk to your radiotherapist by intercom.
Radiotherapy to the bladder area may irritate the bowel and cause diarrhoea and soreness around the anus (opening of the bowel to the outside). It can also cause inflammation of the bladder (cystitis) which makes you want to pass urine more often and causes a burning feeling when you pass urine. Your doctor can prescribe medicines to reduce this. These effects usually disappear gradually a few weeks after the treatment has ended.
Effects on the skin
Perfumed soaps, creams or deodorants may irritate the skin and should not be used during the treatment. At the beginning of your treatment you'll be given advice on how to look after the skin in the area being treated.
Effects on the vagina
For women, radiotherapy to the pelvis can make the vagina narrower, and this can make sex difficult or uncomfortable.
This can be avoided by keeping the muscles in the vagina as supple as possible. Hormone creams applied to the vagina can help and these can be prescribed by your doctor.
One of the best ways of overcoming this problem is to start having sex regularly as soon as you feel ready. If you do not have a regular sexual partner you can use a vaginal dilator. Your nurse or doctor can show you these and explain how to use them.
Effects on ability to have erections
For men, radiotherapy to the pelvis can make it more difficult to have an erection. There are different treatments which can help. Our booklets on sexuality and pelvic radiotherapy in men have more information about this.
Radiotherapy can also cause general side effects such as tiredness. These side effects can be mild or more troublesome, depending on the strength of the radiotherapy dose and the length of your treatment. The radiotherapist will tell you what to expect.
It's important to try to get as much rest as you can, especially if you have to travel a long way for treatment each day.
Loss of pubic hair
During radiotherapy to the pelvis you may lose some of your pubic hair. When you have finished the course of treatment, the hair will often grow back. However, the hair may be thinner than it was before.
After your radiotherapy treatment you will have regular cystoscopies to check the inner lining of the bladder for any recurrence of the cancer.
Possible long-term side effects
In a small number of people, the bowel or bladder may be permanently affected by the radiotherapy. If this happens the increased bowel motions and diarrhoea may continue, or you may need to pass urine more often than before. The blood vessels in the bowel and bladder can become more fragile after radiotherapy treatment and this can make blood appear in the urine or in bowel movements. This can take many months or years to happen. If you notice any blood in your urine or stools it is important to let your doctor know so that tests can be done and appropriate treatment given.
We have further information about treatments for the long-term side effects of pelvic radiotherapy.
Radiotherapy to the pelvic area is likely to cause infertility in men and women. If you have concerns about your fertility it's important to talk to your doctor before your treatment starts.
Chemotherapy for invasive bladder cancer
When it is given
Chemotherapy is the use of anti-cancer (cytotoxic) drugs to destroy cancer cells. If the cancer has spread into the muscle of the bladder, or to other parts of the body, the chemotherapy drugs are given intravenously (into the vein). This is done so that they can circulate in the bloodstream and reach the cancer cells anywhere in the body.
In bladder cancer chemotherapy may be given:
A combination of different drugs are usually given over a few days. You will usually be given the drugs again every few weeks over a period of several months. The drugs most commonly used to treat bladder cancer are cisplatin, carboplatin, methotrexate, vinblastine, gemcitabine (Gemzar®) and doxorubicin.
A combination of the drugs methotrexate, vinblastine, doxorubicin and cisplatin (called MVAC for short) is often used to treat bladder cancer. Other common combinations are cisplatin, carboplatin, methotrexate, vinblastine, gemcitabine (Gemzar®) and doxorubicin.
Chemotherapy drugs can cause side effects, but these can usually be well controlled with medicines.
Lowered resistance to infection Chemotherapy can reduce the production of white blood cells by the bone marrow, making you more prone to infection. Contact your doctor or the hospital straight away if:
You will have a blood test before having more chemotherapy, to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if the number of blood cells (blood count) is still low.
Bruising or bleeding Chemotherapy can reduce the production of platelets, which help the blood to clot. Let your doctor know if you have any unexplained bruising or bleeding, such as nosebleeds, bleeding gums, or blood spots or rashes on the skin.
Anaemia (low number of red blood cells) You may become anaemic. This can make you feel tired and breathless.
Feeling sick (nausea) and being sick (vomiting) Your doctor can prescribe very effective anti sickness drugs (anti- emetics) to prevent or reduce this. Our information on controlling nausea and vomiting may be useful.
Sore mouth Some chemotherapy drugs can make your mouth sore and may cause small ulcers. Your nurse will show you how to look after your mouth and give you special mouthwashes to take regularly.
Poor appetite If you don't feel like eating during treatment, you can try replacing some meals with nutritious drinks or a soft diet. Our booklet on eating well has some useful tips on coping with eating problems.
Hair loss Some chemotherapy drugs may make your hair fall out. If you lose your hair there are many ways of covering up, including wigs, hats or scarves. You may be entitled to a free wig from the NHS. Your doctor or nurse can arrange for a wig specialist to visit you. Your hair should start to grow back again within about 3-6 months of the end of treatment.
Feeling tired Many people feel tired during chemotherapy, particularly towards the end of treatment. This is a common side effect and it's important to get as much rest as you need.
Although they may be hard to deal with at the time, these side effects will gradually disappear after your treatment is over.
Early menopause Chemotherapy may make some women have an early menopause. But bladder cancer is rare under 50 so you may already have had your menopause or be going through it.
Your doctor will advise you on how menopausal symptoms, which can include hot flushes and vaginal dryness, can be treated.
It is not advisable to become pregnant or father a child while taking any of the chemotherapy drugs used to treat bladder cancer, as they may harm the developing foetus. It's important to use effective contraception during your treatment and for up to a year afterwards. You can discuss this with your doctor or specialist nurse.
Condoms should be used during sex for the first 48 hours after chemotherapy. This is to protect your partner from any of the drug that may be present in semen or vaginal fluid.
Treatment for advanced bladder cancer
Chemotherapy is often given when the cancer has spread outside the bladder to other parts of the body. It can help to shrink or slow down the growth of the cancer and reduce your symptoms. It may also help you to live longer.
You may be given a short course of radiotherapy to the bladder to improve any symptoms. Radiotherapy can also be given to relieve pain if the cancer has spread to the bones (palliative radiotherapy).
The type of chemotherapy you have will depend on how advanced your cancer is and how physically well you are. You may be given a combination of drugs like MVAC (methotrexate, vinblastine, doxorubicin and cisplatin) or GC (gemcitabine and cisplatin) or a chemotherapy drug on its own.
Many people worry about having chemotherapy because of the possible side effects. But these side effects can usually be well controlled with medicines.
Making treatment decisions when you have advanced cancer can be difficult. It's important to talk to your doctor about the advantages and disadvantages in your particular situation. Talking it over with your family and close friends may also be helpful.
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